Depredation of catch by sharks is an emerging issue facing recreational, commercial and charter fishers worldwide involving the interplay of a complex array of environmental, behavioural and operational factors. Since 2021, applied research has been undertaken in Queensland fisheries to determine the significance of shark depredation and identify influencing factors using a multi-modal approach involving genetic analysis, underwater observation, citizen science and shark movement monitoring. This allowed the frequency of depredation events to be determined, actual depredation events and shark behaviour to be visualised, responsible depredating species to be identified and influencing factors to be analysed. To address rising sustainability concerns regarding the future of fisheries in Queensland, strategies to mitigate catch depredation have also been investigated, such as the effectiveness and practicality of shark repellents during actual fishing operations. As this research nears completion, an update will be provided on the findings to date, which will aid in informing future policy and management methods to ensure sustainable fisheries into the future.